TY - JOUR AU - Zhou, Hui AU - Li, Junhong AU - Wei, Hailian AU - Li, Aifeng AU - Wang, Xiuping AU - Zhang, Xiaonan AU - Lu, Qiteng AU - Chen, Siyuan AU - Wei, Zhixiao PY - 2020 TI - A novel timesaving and semiquantitative method for radionuclide hepatobiliary scintigraphy for suspected biliary atresia JF - Annals of Palliative Medicine; Vol 9, No 1 (January 2020): Annals of Palliative Medicine Y2 - 2020 KW - N2 - Background: To optimize the performance of the hepatobiliary scintigraphy (HS) for suspected biliary atresia (BA) using a timesaving and semiquantitative method without a loss in diagnostic accuracy. Methods: A retrospective analysis of 185 patients with persistent jaundice who underwent surgery were included. According to the surgical evaluation and pathological diagnosis, patients were divided into a BA group (99 cases) and an infant hepatitis syndrome (IHS) group (86 cases). 99mTc-labeled diethylacetanilide- iminodiacetic acid (99mTc-EHIDA) HS was performed before surgery. The average intestinal radioactivity uptake value minus the background average of radioactivity uptake value at 6 h after label injection (abbreviated as 6-h I-B) was calculated and the difference in 6-h I-B between the two groups was evaluated. The difference in diagnostic efficacy between 6-h I-B and the conventional 24-h HS in BA was also evaluated. Results: A significant difference in 6-h I-B between the two groups was found (t=−5.975, P Conclusions: HS plays an important role in the diagnosis of infantile jaundice due to conjugated hyperbilirubinemia. The timesaving and semiquantitative method of the 6-h hepatobiliary static imaging showed the same high sensitivity and NPV of the conventional 24-h HS in preventing unnecessary surgery. In the setting of suspected BA, imaging resource utilization could be improved via reducing the acquisition time and simplifying the examination process. The 24-h delay in imaging was considered unnecessary because it was not significantly superior. UR - https://apm.amegroups.com/article/view/34110