Effects of moxibustion on gastrointestinal function recovery in preventing early postoperative small-bowel obstruction: a meta-analysis
Original Article

Effects of moxibustion on gastrointestinal function recovery in preventing early postoperative small-bowel obstruction: a meta-analysis

Lili Yang1,2#^, Zhengjun Li3,4#^, Wenlin Li2^, Li Zeng1,2^, Yaoyao Bian5^

1School of First Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China; 2Jingwen Library, Nanjing University of Chinese Medicine, Nanjing, China; 3College of Health Economics Management, Nanjing University of Chinese Medicine, Nanjing, China; 4School of Management, University of St Andrews, St Andrews, UK; 5School of Nursing, Nanjing University of Chinese Medicine, Nanjing, China

Contributions: (I) Conception and design: Y Bian, L Zeng; (II) Administrative support: L Yang, Y Bian; (III) Provision of study materials or patients: L Yang, Z Li, Y Bian; (IV) Collection and assembly of data: Z Li, W Li; (V) Data analysis and interpretation: L Yang, Y Bian, L Zeng; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

#These authors contributed equally to this work.

^ORCID: Lili Yang, 0000-0001-5220-3094; Zhengjun Li, 0000-0001-8208-3898; Wenlin Li, 0000-0002-7105-2743; Yaoyao Bian, 0000-0002-9968-2501; Li Zeng, 0000-0002-9095-9439.

Correspondence to: Prof. Yaoyao Bian, PhD. School of Nursing, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing 210023, China. Email: bian@njucm.edu.cn; Prof. Li Zeng, PhD. School of First Clinical Medicine and Jingwen Library, Nanjing University of Chinese Medicine, 138 Xianlin Rd, Nanjing 210023, China. Email: zengbingli@njucm.edu.cn.

Background: Moxibustion is widely used in the recovery of gastrointestinal function in East Asian countries, especially in China. This systematic review aims to evaluate the recovery effects of moxibustion on gastrointestinal function in preventing early postoperative small-bowel obstruction (EPSBO).

Methods: The Medline, Embase, PubMed, and the other seven databases were searched independently by two authors. Randomized controlled trials (RCTs) were selected using the PICOS method. The methodological quality was appraised with the Cochrane’s risk of bias tool, and the reporting quality of included studies was evaluated by Consolidated Standards of Reporting Trials (CONSORT) and STandards for Reporting Interventions in Clinical Trials of Moxibustion (STRICTOM), respectively. Revman 5.2.0 was used for statistical analysis, and the mean difference (MD) with 95% confidence interval (CI) was performed for effect estimation. Random effects model (REM) and fixed effects model (FEM) were used for pooling data.

Results: A total of 8 RCTs with 693 participants were included. Meta-analysis showed that moxibustion combined with usual care had favorable effects on the time to first flatus (MD −15.15 h, 95% CI: −19.14 to −11.15, 8 studies, I2=85%, P<0.00001, REM), the time to bowel sound recovery (MD −10.35 h, 95% CI: −11.65 to −9.06, 7 studies, I2=0%, P=0.91, FEM), the time to first defecation (MD −18.94 h, 95% CI: −24.53 to −13.36, 3 studies, I2=45%, P=0.16, FEM), and the duration time to abdominal distention (MD −11.7 h, 95% CI: −15.32 to −8.09, 3 studies, I2=0%, P=0.70, FEM) when compared to the controls. No adverse events were reported in the included studies.

Conclusions: Moxibustion may have a beneficial effect on the recovery of gastrointestinal function in preventing EPSBO. However, positive findings should be treated carefully. And rigorous studies with high quality and large samples are warranted.

Keywords: Moxibustion; recovery of gastrointestinal function; early postoperative small bowel obstruction; meta-analysis

Submitted Jun 15, 2020. Accepted for publication Jan 15, 2021.

doi: 10.21037/apm-20-1266


Early postoperative small bowel obstruction (EPSBO) is a normal response to tissue injury that occurs within two weeks after abdominal surgeries (1,2). It is usually related to the dysfunction of gastrointestinal motility (3). Patients with small-bowel obstruction often cannot eat, pass flatus, or defecate within five days after a laparotomy or minimally invasive surgery (4). Its clinical features include abdominal pain, vomit, abdominal distension, dyschezia, and radiographic confirmation (5). It is reported that the incidence rates of EPSBO ranged from 0.69% in 1987 (6) to 9.5% in 2002 (1). And it is estimated that the mortality rates widely ranged from 2.4% to 15% (7-9).

Pickleman et al. (10) suggested that EPSBO is caused by adhesion, inflammation, and that non-operative therapy should be treated first. Currently, effective prevention and treatment is nasogastric decompression (11). If EPSBO is not resolved, eventual re-operation will be needed. It is not easy to find obstruction sites. And the re-operation can also cause intestinal injury and expand the extent of the operation, thereby resulting in postoperative bleeding, infection, intestinal fistula, and other complications. Moreover, it may reoccur or aggravate bowel obstruction. It not only extends hospitalization (12) and increases costs (13), but also creates discomfort and increases related postoperative complications (e.g., pulmonary complications) (14,15). Therefore, early prevention and treatment of EPSBO are essential.

Thus far, complementary, and alternative therapies, especially Chinese therapy represented by moxibustion, have gained more and more attention from researchers due to their significant therapeutic potency in preventing and treating diseases. Moxibustion (moxa) is a kind of traditional oriental medicine, which originated from the meridian-collateral theory of traditional Chinese medicine (TCM). It has been used in East Asian medicine for more than a thousand years (16). It is a type of thermal therapy that stimulates specific acupoints through healing. This therapy is generated by burning dried herbs called mugwort leaves (Artemisia vulgaris). Moxibustion is widely accepted in East Asian countries, as well as throughout the world. Increasing evidence indicates that it can unblock the meridians and collaterals, and regulate the qi and blood function of the spleen and stomach (17), thereby preventing nausea and vomiting (18), improving dyschezia and other main gastrointestinal symptoms (19). As the study reported that moxibustion could improve intestinal motility (20), indicating a potential method in preventing EPSBO. However, insufficient evidence is still lacking to reach a conclusion on this issue.

Herein, this systematic review aims to increase the existing level of evidence by evaluating the critical effects of moxibustion on preventing EPSBO. To our knowledge, this is the first meta-analysis using randomized controlled trials (RCTs) to review the gastrointestinal outcomes on this subject. We presented the following study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting checklist (available at http://dx.doi.org/10.21037/apm-20-1266).


Search strategy

A total of 10 electronic databases ranging from their inception dates to April 30, 2019, i.e., Cochrane Central Register of Controlled Trials, Manual, Alternative and Natural Therapy Index System, Allied and Complementary Medicine Database (AMED), PubMed, Embase, Medline, and four Chinese medicine databases, including China National Knowledge Infrastructure (CNKI) Database, Wanfang database, Chinese Science and Technology Periodical Database (VIP), and Chinese Biomedical Database (CBM) were searched, as well as databases that contained relevant ongoing trials, such as US equivalent clinical trial registry (http://www.clinicaltrials.gov). The search language was restricted to English and Chinese. The keywords used to search for RCTs were: “moxibustion” OR “moxibustion therapy” OR “moxa-moxibustion” OR “warm-moxibustion” OR “complementary therapies” OR “Chinese medicine” OR “traditional medicine” OR “alternative medicine” OR “complementary medicine” AND “postoperative small-bowel obstruction” OR “postoperative ileus” OR “EPSBO” OR “gastrointestinal function recovery” OR “gastrointestinal disorder” AND “randomiz*”. All eligible studies were reviewed, and all relevant data were identified by two review authors (L Yang and Y Bian). Any unresolved disagreements were discussed with a third review author (Z Li).

Inclusion criteria

Studies that met the PICOS (population, intervention, comparator, outcome, study type) criteria were included: (I) participants: patients regardless of age, gender, original disease, or type of surgery and anesthesia, who underwent abdominal or gastrointestinal surgery without experiencing postoperative small-bowel obstruction or any complications; (II) interventions: moxibustion at the acupoints alone or moxibustion combined with usual care; (III) comparators: usual care, e.g., fasting, gastrointestinal decompression, postoperative early mobilization and parenteral nutrition support; (IV) outcomes: the time to first flatus, the time to bowel sound recovery, the time to first defecation, and the duration time of abdominal distention. Bowel sounds were recorded at four quadrants of the abdomen with a standard interval (often every 2 h) after operation; and (V) study type: RCTs.

Exclusion criteria

Studies that met the following criteria were excluded: (I) quasi-RCTs and non-RCTs; (II) reviews, case series, case reports, or animal studies; (III) participants who received diagnostic surgery for definite diagnosis (e.g., endoscopy); (IV) intervention, including moxibustion combined with other traditional therapies (e.g., acupuncture, retention enema with Chinese herbal medicine, and acupoint massage); and (V) studies with insufficient outcome data or unsuitable for analysis.

Data extraction and quality assessment

The two reviewers (Y Bian and L Yang) extracted the relevant data independently according to a predefined form. The characteristics of the included studies were author information, date of publication, participant characteristics, sample size, interventions, outcomes, and results. A consensus was reached through a discussion with the third reviewer (Z Li) in case of any discrepancies. The author was contacted to obtain the relevant data if the information was inadequate. The primary effectiveness outcomes assessed were the time to first flatus, the time to bowel sound recovery, and the time to first defecation; the secondary effectiveness outcome was the duration time of abdominal distention. The safety outcomes were the adverse events including any complications caused by moxibustion.

Cochrane’s risk of bias tool was used to assess the methodological quality of RCTs (version 5.1.0) (21). The seven items followed a random sequence generation (selection bias), allocation concealment (selection bias), blinding of outcome assessment (selection bias), blinding of participants and personnel (performance bias), incomplete outcome data (attrition bias), selective reporting (reporting bias), and other biases. Each research result was judged as “low” for low-degree bias, “high” for high-degree bias, and “unclear” for uncertain bias conditions. Quality of reporting was performed using the Consolidated Standards of Reporting Trials (CONSORT) 2010 (available from http://www.consort-statement.org/) and STandards for Reporting Interventions in Clinical Trials of Moxibustion (STRICTOM) (22) on full-texts. STRICTOM is developed based on the CONSORT, a statement for RCTs, and Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) (available from http://www.stricta.info/), a wide guideline for RCTs of acupuncture. Each item of the statements was judged as “Yes” for adequately reported, and “NO” for not adequately reported. Two review authors (Y Bian and L Yang) cross-verified the methodological and reporting quality of the eligible studies, respectively. Disagreements were resolved through a discussion with a third review author (Z Li) and consensus.

Statistical analysis

Revman 5.2.0 software (available from the website for free: http://www.ccims.net/revman/download) was used for data analyses. For continuous outcomes of moxibustion, the mean difference (MD) with 95% confidence interval (CI) was used to calculate the effect size. Before merging the statistics, all studies were tested for heterogeneity using the chi-square and I2 tests. Forest plots were constructed for each outcome. The fixed-effect model was used if P>0.1 and I2<50%, which indicated homogeneity. Otherwise, a random-effect model was applied for the analysis (23). Subgroup analysis was presented based on the pre-specified study-level characteristics (e.g., type of surgery, type of intervention, and type of comparators). Besides, Egger tests were generated to examine the publication bias, and the trim-and-fill computation was used to estimate the effect of publication bias on the interpretation of the results (24).


Study selection

Totally, 1,198 relevant articles were identified, in which 389 duplicate records were excluded. The remaining 809 studies were selected based on their titles and/or abstracts. A total of 776 studies were removed according to the inclusion criteria, leaving 33 full-text publications for further screening. Finally, eight RCTs (25-32) were included in this review, all of which were published in Chinese. Figure 1 shows the entire process of trial selection.

Figure 1 Flowchart of the trial selection process.

Study characteristics

The characteristics of the included trials are presented in Table 1. A total of 693 abdominal postoperative participants (345 in the intervention group and 348 in the controls) were included.

Table 1
Table 1 Summary characteristics of the included studies
Full table

The experimental interventions of all studies (25-32) used the moxibustion combined with usual care. The controls were usual care, including fasting, gastrointestinal decompression, parenteral nutrition support, and postoperative early mobilization. All studies reported the time to first flatus, seven studies (25-27,29-32) reported the time to bowel sound recovery with clear reporting standards, three studies (28,29,31) reported the time to first defecation, and two studies (28,30) reported the duration time to abdominal distention.

Risk of bias assessment

Although all studies mentioned “random allocation”, only four studies (27,29,30,32) reported appropriate methods of sequence generation for the randomization. The remaining studies (25,26,28,31) did not describe the methods of sequence generation. None of the studies stated allocation concealment and dropout/withdrawal or mentioned blinding of outcome assessors. And none of the studies performed blinding to participants and personnel. This approach might be considered as a high risk of bias. The Cochrane risk of bias is presented in Figures 2,3.

Figure 2 Risk of bias graph.
Figure 3 Risk of bias summary.

Reporting quality

All RCTs were appraised based on the 25 standards of the CONSORT statement. In general, the included studies have poor reporting quality. All eligible studies mentioned demographic and clinical baseline characteristics. And most studies reported complete scientific background, intervention, statistical methods, and definition of the pre-specified primary outcome measures. However, the description of trial design, sample size estimate, methods of random allocation, concealment and blinding, trial limitations, and protocol registering were not fully reported in all included studies. The main detailed results based on CONSORT are listed in Table S1.

All RCTs were also assessed based on the 7 items and 16 sub-items of the STRICTOM. Two items (moxibustion rationale about the type of moxibustion, reasoning for choosing, and treatment regimen about the number, frequency, and duration of moxibustion corresponding with STRICTOM 1a, 1b, and 3) were well-stated in all studies. And all studies mentioned details of moxibustion including names of acupoints, and the time per acupoint. Most studies (25-27,29-31) reported detailed features, procedures, or techniques for moxibustion intervention, as well as control treatment in detail. However, none of the included studies stated the background of the practitioner, information/explanations to patients, and reasoning for choosing the control treatment. In addition, patient posture, treatment environment, and any precaution measures were not reported in any studies. The detailed findings based on STRICTOM are presented in Table S2.


Time to first flatus

All studies reported the time to first flatus, and a random-effects model was used. The meta-analysis showed that moxibustion combined with usual care had statistically significant effects on shortening the time to first flatus than usual care alone [MD −15.15 h, 95% CI: −19.14 to −11.15, 8 studies, I2=85%, P<0.00001, random effects model (REM)]. The forest plots of the time to first flatus are shown in Figure 4. Excluding two studies (28,32), the remaining studies were used for sensitivity analysis, and the heterogeneity disappeared. A fixed-effect model was used for further analysis, which showed that the time to first flatus in the intervention group was still shorter than the time in the controls. Statistical heterogeneity was found among the remaining six studies (25-27,29-31) [MD −11.31 h, 95% CI: −12.84 to −9.78, 6 studies, I2=11%, P=0.35, fixed effects model (FEM); Figure 5].

Figure 4 Forest plots of time to first flatus.
Figure 5 Sensitivity analysis of time to first flatus.

Time to bowel sound recovery

Seven studies (25-27,29-32) reported the time to bowel sound recovery and a fixed effect model was used. The meta-analysis suggested that moxibustion combined with usual care had statistically significant effects on shortening the time to bowel sound recovery than usual care alone (MD −10.35 h, 95% CI: −11.65 to −9.06, 7 studies, I2=0%, P=0.91, FEM; Figure 6A).

Figure 6 Forest plots within two groups. (A) Time to bowel sound recovery; (B) time to first defecation; (C) duration time of abdominal distention.

Time to first defecation

Three studies (28,29,31) reported the time to first defecation and a fixed-effect model was utilized. The result suggested that moxibustion combined with usual care showed better effects on reducing the time to first defecation when compared to the usual care alone (MD −18.94 h, 95% CI: −24.53 to −13.36, 3 studies, I2=45%, P=0.16, FEM; Figure 6B).

Duration time of abdominal distention

Two studies (28, 30) reported the duration of abdominal distention, and a fixed-effect model was employed. The meta-analysis showed that moxibustion combined with usual care had better effects on decreasing the duration time of abdominal distention in comparison with the usual care alone (MD −11.7 h, 95% CI: −15.32 to −8.09, 3 studies, I2=0%, P=0.70, FEM; Figure 6C).

Safety outcomes

No study reported adverse events.

Publication bias

We assessed the possible publication bias using Egger tests, and defined significant publication bias as a P value < 0.1. The results of Egger tests showed P=0.180 for the time to first flatus and P=0.329 for the time to first defecation when compared with the controls, indicating no potential publication bias in the selected studies. In this analysis, there was publication bias in the time to bowel sound recovery (P=0.053). However, further analysis with the trim-and-fill test indicated that this publication bias did not affect the estimates (i.e., no trimming done because data were unchanged).


EPSBO is defined as “epigastric pain,” “qi stagnancy,” “intestinal mass,” and “accumulation” in TCM theory. It is a common condition after abdominal surgery. EPSBO is caused by viscera dysfunction, intestinal obstruction, qi stagnation, and blood stasis, which is called “hindering pain.” Meanwhile, it is also caused by the consumption of qi and blood, the nutritional deficiency of the viscera, which is also called “deficiency pain.” Danxi Zhu, a traditional Chinese physician, suggested that the blood runs through the blood vessels smoothly when it’s warm. Conversely, the blood will be blocked when it’s cold. It’s reported that all diseases caused by the stagnation of qi and blood can be treated with moxibustion (33).

Moxibustion therapy is an integral part of TCM, which has been used to treat and prevent diseases for more than 2,500 years. It is less well known in western countries than acupuncture due to the lack of modern medical evidence. Moxibustion is a traditional therapeutic remedy that is performed to obtain heat irritation by burning crushed dry moxa near or on the skin at certain acupoints. This therapy warms the interior and dissipates the cold, regulates qi and resolves stasis, softens and dissolves mass, resuscitates yang, and warms the meridians. Modern studies (34,35) found that moxibustion can obtain excellent lasting effects on regulating gastrointestinal motility and promoting gastrointestinal function recovery, which is consistent with our study.

The review of 8 RCTs (693 participants) evaluated the gastrointestinal function of moxibustion on preventing EPSBO. Moxibustion combined with usual care could effectively shorten the time to first flatus, the time to bowel sound recovery, and the time to first defecation. Meanwhile, moxibustion could shorten the duration time to abdominal distention than usual care alone, suggesting that moxibustion may improve the recovery effects of gastrointestinal function and have beneficial effects on preventing EPSBO.

Although the intervention of the studies was about moxibustion, the selection of the moxibustion acupoints was different. The main points were ST36 (6 articles), ST37 (4 articles), RN12 (4 articles), RN8 (3 articles), and ST25 (2 articles). ST36 is located on the stomach meridian. It can adjust the intestine and stomach, harmonize qi and blood, and calm the rising of qi in the stomach, thereby promoting gastrointestinal function. RN12 is an intersecting acupoint of the ren channel, small intestine meridian, triple energizer meridian, and stomach channel of foot-yangming. Moxibustion on RN12 can harmonize meridians and collaterals of the intestine and stomach. ST37 is the lower confluent acupoint of large and small intestines with the function of regulating the intestine, promoting the flow of qi, and removing qi stagnation. RN8 is an acupoint of ren meridian that smoothens the qi of the intestine and stomach, regulates yin-yang and qi-blood, promotes gastrointestinal functions, and alleviates abdomen distention. ST25 is the front mu acupoint of the large intestine that can adjust the functions of zang-fu and regulate the flow of qi to activate stagnancy. Moxibustion on the above acupoints has warm stimulating effects to run qi-blood and meridian, thereby recovering gastrointestinal function.

This study was the first review about moxibustion for gastrointestinal function recovery in preventing EPSBO. All eligible studies were appraised by Cochrane’s risk of bias tool for methodological quality, and assessed by the CONSORT and STRICTOM checklists for reporting quality, respectively. Thus, certain limitations can still be observed.

First, significant heterogeneity of the time to first flatus was observed. This could be explained by the clinical heterogeneity. The outcome of the first flatus, a subjective indicator, was highly dependent on the participant’s self-reporting that is difficult to measure with an objective assessment tool. When assessing the outcomes, the clinicians could not rule out the subjective factors and individual differences of the participants. It may eventually cause high heterogeneity. The other subjective outcomes (e.g., abdominal distention or first defecation) were also likely to have the same problem. These factors might influence the credibility of the results to a certain extent. Thus, objective assessment methods are required for future study of EPSBO prevention. Additionally, based on the CONSORT checklist and Cochrane’s risk of bias, most studies did not report the methods on how to generate a random sequence. The unclear or less rigorous “randomization” may due to insufficient reporting of generation methods of allocation sequence, allocation concealment, and blinding. It may also influence internal validity and cause the overestimation of the actual therapeutic effect, which might cause selection bias. Because of the specificity of moxibustion therapy, it is hard to perform blinding methods and allocation concealment to participants and personnel. Furthermore, the patient can easily distinguish the sham moxibustion from the real one. That is why all included studies in our review used usual care as a control rather than sham moxibustion. However, a kind of sham moxa device as placebo made it possible to conduct randomized double-blind, placebo-controlled clinical trials of moxibustion (36). Due to the lack of double-blind control, moxibustion can be easier to achieve a beneficial effect than controls. Hence, more rigorous RCTs with adequate allocation concealment, double-blinding methods, and using sham moxibustion as a placebo are needed to evaluate the true effect of moxibustion in enhancing gastrointestinal function in preventing EBPSO. Moreover, future studies with sample size estimates and adverse events in detail are also recommended.

Second, concerning the STRICTOM statement, none of the studies reported the patient’s posture, treatment environment, and background of the treatment providers. The first two aspects are very important external factors that affect the whole process of moxibustion. Because the details of the patient’s posture and treatment environment determine whether the results can be repeated. The background of the treatment providers in detail is one of the preconditions of moxibustion procedures to reach standardization and normalization. Any differences regarding qualification or affiliation of practitioners, experience in moxibustion practice may influence the therapeutic effect of moxibustion directly. Moreover, the effect of moxibustion on gastrointestinal function is also associated with details of moxibustion, e.g., the type of moxibustion, the selection of acupoints, the frequency of treatment session, and responses sought. Although the studies in our review had mentioned the above details, the various kinds of acupoints selected and the intensity of stimulation sought are not equivalent among the studies. The diversity of factors will lead to the incomparability of the outcomes and a high risk of bias among studies. So we suggested that researchers should consider the guideline of STRICTOM to design more rigorous RCTs with high quality about moxibustion.

Third, no studies reported adverse events; thus, the safety of moxibustion on gastrointestinal function cannot be assessed because of insufficient evidence. Only one study (28) reported that three participants in the control group had eventual reoperation, whereas the remaining studies did not report the adverse events. If EPSBO cannot be resolved, when will the subsequent reoperation be needed? Hence, the duration of moxibustion therapy for recovering gastrointestinal function in preventing EPSBO needs to be further studied.

Fourth, all studies were conducted in China, which might cause language bias. Considering that moxibustion is also one of the most widely used medical technology in Korea and Japan. Further studies should include subjects from East Asian countries. Besides, all the studies were selected from the conference paper or academic thesis, and the negative trials might not be reported. Additional databases, including gray literature, should be considered to avoid publication bias.

Fifth, the sample size was relatively small for a country of 1.4 billion people, and the smallest one had 20 cases in the control group (31). To avoid false-positive conclusions, further study should require a large sample size for RCTs to provide high levels of evidence.


In this systematic review, moxibustion might have a beneficial effect on gastrointestinal function recovery in preventing EPSBO. However, the small sample size, high risk of bias, low methodological quality, and poor reporting quality among the included studies influenced the credibility of the positive findings. Future rigorous studies with high quality and large samples are warranted to support the clinical benefit of moxibustion therapy on gastrointestinal function. We also suggest that clinical investigators refer to the extension of the CONSORT and STRICTOM standards for clinical trials of moxibustion to standardize the quality of RCTs and improve research transparency.


Funding: This work was supported by the National Natural Science Foundation of China (No. 81704084 and 81673982), the Natural Science Foundation of Nanjing University of Chinese Medicine (No.NZY81704084), the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), the Open Projects of the Discipline of Chinese Medicine of Nanjing University of Chinese Medicine Supported by the Subject of Academic priority discipline of Jiangsu Higher Education Institutions (No.ZYX03KF63), the advantages of nursing discipline project of Jiangsu province (2019YSHL005), and Qing Lan Project (No. 014000773/2018-00376).


Reporting Checklist: The authors have completed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. Available at http://dx.doi.org/10.21037/apm-20-1266

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/apm-20-1266). The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.


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Cite this article as: Yang L, Li Z, Li W, Zeng L, Bian Y. Effects of moxibustion on gastrointestinal function recovery in preventing early postoperative small-bowel obstruction: a meta-analysis. Ann Palliat Med 2021;10(4):3988-3999. doi: 10.21037/apm-20-1266