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Plasma parameters and risk factors of patients with post-stroke cognitive impairment

	author = {Ji-Xia Wu and Jian Xue and Lei Zhuang and Chun-Feng Liu},
	title = {Plasma parameters and risk factors of patients with post-stroke cognitive impairment},
	journal = {Annals of Palliative Medicine},
	volume = {9},
	number = {1},
	year = {2020},
	keywords = {},
	abstract = {Background: It is high of the incidence of stroke and dementia with the advent of an aging society. Post- stroke cognitive impairment is one of the common complications of stroke, which not only seriously affects the life quality of patients, but also significantly reduces the survival time of stroke patients. Moreover, it also brings in heavy burden to the family and society. The development of vascular dementia could be reduced by early intervention after stroke. Management of vascular risk factors could be an effective way to prevent dementia. This study aimed to investigate the plasma biochemical parameters of post-stroke cognitive impairment (PSCI) and its potential risk factors.
Methods: Four hundred eighty-seven consecutive patients with ischaemic stroke were included and followed up for 3 years. Among these patients, 132 cases were diagnosed as PSCI. The cognitive impairment of patients with PSCI was assessed by the Mini Mental State Examination and Montreal cognitive assessment scale. The plasma biochemical parameters and blood coagulation, as well as computed tomography and magnetic resonance imaging of all the patients after admission, were measured.
Results: Multivariate analyses revealed that increased age, carotid plaque, cerebral atrophy, white matter lesions (WML), alcohol use, smoking and history of systolic blood pressure ≥170 mmHg was highly associated with PSCI (P},
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