%0 Journal Article %T Image-guided intensity-modulated radiotherapy improves short-term survival for abdominal lymph node metastases from hepatocellular carcinoma %A Zhang, Haige %A Chen, Yixing %A Hu, Yong %A Yang, Ping %A Wang, Binliang %A Zhang, Jianying %A Sun, Jing %A Zeng, Zhaochong %J Annals of Palliative Medicine %D 2019 %B 2019 %9 %! Image-guided intensity-modulated radiotherapy improves short-term survival for abdominal lymph node metastases from hepatocellular carcinoma %K %X Background: Radiotherapy (RT) is an effective treatment for hepatocellular carcinoma (HCC) patients with lymph node metastasis (LNM), which is a rare clinical situation with a poor prognosis. We evaluated the responses and toxicities in HCC patients with abdominal LNM treated with either image-guided intensity- modulated radiotherapy (IG-IMRT) or non-IG-IMRT. Methods: Retrospective review of the records of HCC patients with regional LNM treated with IG-IMRT (n=43) or non-IG-IMRT (n=42). The tumor responses, local control rates (LCRs), overall survival (OS) rates, and toxicities were evaluated. Results: The mean biological effective dose with α/β =10 Gy (BED 10 ) delivered to IG-IMRT group was 67.23±8.48 vs . 63.43±5.01 Gy delivered to non-IG-IMRT group (P=0.008). OS in IG-IMRT group vs . non- IG-IMRT group was 15.3 vs . 9.7 months (P=0.098). The one-year survival of IG-IMRT group was superior (69% vs . 38.1% for non-IG-IMRT, P=0.006). Whereas two-year survival was not significantly different. Negative independent prognostic factors included ≥2 positive lymph nodes and previous treatment without surgery, while BED 10 ≥65 Gy was a protective factor. Toxicities were mild for both groups, while IG-IMRT group showed less late hepatotoxicity. Conclusions: The therapeutic dose delivered by IG-IMRT is slightly higher than non-IG-IMRT which was more effective and showed superior short-term survival and local control in HCC patients with LNM. %U https://apm.amegroups.org/article/view/32182 %V 8 %N 5 %P 717-727 %@ 2224-5839