TY - JOUR AU - Kamal, Arif H. AU - Peppercorn, Jeffrey M. PY - 2013 TI - The generalizability paradox within palliative care clinical trials JF - Annals of Palliative Medicine; Vol 2, No 2 (April 28, 2013): Annals of Palliative Medicine Y2 - 2013 KW - N2 - We are increasingly recognizing that personalized advanced and chronic illness care requires meticulous assessment and management of supportive care needs across the entire disease trajectory. This requires drawing clinical decisions from a research evidence base that is presumably generalizable to a heterogeneous patient population, often with poor performance status, multi-morbidity, and a large symptom distress profile. As sometimes this is not the case, how do we improve evidence generation that can be consistently applied to all patients with advanced disease? UR - https://apm.amegroups.org/article/view/1638