Comparison of the effects of general and local anesthesia in lumbar interlaminar endoscopic surgery
Original Article

Comparison of the effects of general and local anesthesia in lumbar interlaminar endoscopic surgery

Xue-Fei Ye1#, Sheng Wang2#, Ai-Min Wu2, Lin-Zheng Xie2, Xiang-Yang Wang2, Jiao-Xiang Chen2, Hui Xu2, Sun-Ren Sheng2

1Department of Anesthesiology, 2Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China

Contributions: (I) Conception and design: SR Sheng; (II) Administrative support: XF Ye; (III) Provision of study materials or patients: AM Wu; (IV) Collection and assembly of data: LZ Xie; (V) Data analysis and interpretation: XY Wang, H Xu; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

#These authors contributed equally to this work.

Correspondence to: Sun-Ren Sheng. Department of Orthopaedic Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China. Email:

Background: Percutaneous endoscopic lumbar discectomy (PELD) with an interlaminar approach is a technique used to treat lumbar disc hernia. It has not yet been established whether general or local anesthesia (LA) is preferable for lumbar interlaminar endoscopic surgery.

Methods: Between October, 2012 and June, 2016, 60 patients were recruited and randomly divided into 2 groups: the general anesthesia (GA) group and the LA group. The patients’ basic clinical data, intraoperative patient experience, Oswestry disability index (ODI), visual analog scale (VAS) score, and the postoperative patient satisfaction rate were assessed.

Results: Statistically significant differences were found between the two groups in operative time and length of hospital stay. There were no significant differences in postoperative ODI or VAS scores between the two groups during follow-up at 3, 6, and 12 months. One patient in the GA group sustained a nerve root injury intraoperatively. Two patients in the LA group suffered adverse reactions, as did six patients in the GA group. However, 50% of the patients expressed fear about undergoing the surgery with LA, while all patients felt they could undergo the same surgery with GA.

Conclusions: General and LA are both suitable for use in lumbar interlaminar endoscopic surgery. However, GA makes a positive intraoperative surgical experience more likely for the patient.

Keywords: Local anesthesia (LA); general anesthesia (GA); lumbar interlaminar endoscopic surgery; effect

Submitted Feb 10, 2020. Accepted for publication May 06, 2020.

doi: 10.21037/apm-20-623


Percutaneous endoscopic lumbar discectomy (PELD) is a standard technique for the treatment of lumbar disc herniation (1-5). In the late 1990s, the interlaminar approach to PELD started to grow in popularity (1,3-6). Both general anesthesia (GA) and local anesthesia (LA) allow endoscopic surgeries, including PELD, to be safely performed (7-9). LA is recommended by most surgeons for PELD because of its rapid onset and lower risk of nerve injury and pulmonary complications, as well as its ability to prevent pressure necrosis, reduce intraoperative blood loss, and provide proper postoperative pain control (2-6). Nevertheless, the use of LA for percutaneous interlaminar endoscopic discectomy is not without complications and can result in nerve root injury, dural tear, hematoma, and intracranial hypertension (10).

Patient satisfaction and the ability of surgeon to perform prolonged operations are two of the main advantages with GA. Desirable intraoperative hemodynamic conditions, including minimal blood transfusion, the earliest possible discharge from the postanesthesia care unit (PACU), and reduced incidence of common postoperative problems, such as pain, analgesic consumption, nausea, and vomiting, are important elements of good anesthesia (11-13). For these advantages, some surgeons prefer GA for percutaneous endoscopic discectomy with an interlaminar approach (8,9).

Controversy still surrounds the feasibility, safety, and efficacy of LA and GA for patients undergoing lumbar interlaminar endoscopic surgery. However, modern GA techniques, such as multimodal nonopioid analgesia and a fast-track approach, have not often been compared with LA. Therefore, this study set out to determine which type of anesthesia has better clinical outcomes.

We present the following article in accordance with the CONSORT reporting checklist (available at


Between October, 2012 and June, 2016, patients diagnosed with lumbar intervertebral disc were recruited for this study at our hospital. In all, 65 consecutive patients were assessed for eligibility by 2 surgeons, and 60 were finally included after a preoperative visit by an anesthetist [Figure 1 (CONSORT flow diagram)].

Figure 1 Consort flow diagram for the study.

The patients were enrolled according to a relatively narrow set of inclusion and exclusion criteria. The inclusion criteria were as follows: (I) diagnosis of lumbar intervertebral disc with one or two contiguous lumbar levels; (II) levels between L4 and S1 affected; and (III) symptoms consistent with the pathology (typically radiculopathy, with or without back pain). Prior lumbar fusion surgery, extreme lateral lumbar disc herniation, spinal metastases or active spinal tumor malignancy, and active local or systemic infection, were the primary reasons for exclusion.

The study received approval from the Research Ethics Committee of The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University. All patients provided written informed consent before undergoing surgery.

The surgeries were performed by two experienced surgeons who had carried out 200 PELD procedures over 4 years. The patients were randomly divided into two groups according to a blinded allocation card at each site. Thirty patients underwent GA administered by an anesthesiologist, and the other 30 patients underwent surgery with LA administered by the surgeon. No local anesthetic was administered to the patients who underwent GA. The patients were followed-up for more than 12 months after the surgery.

Anesthesia methods

The LA group received 0.5% lidocaine in 10 mL, and 0.25% ropivacaine at 1.3 mg/kg was administered to prevent related pain. In the GA group, propofol 2–3 mg/kg, sufentanil 0.2 µg/kg, and cisatracurium 0.2 mg/kg were administered to facilitate endotracheal intubation, and ventilation was controlled to maintain the end-tidal carbon dioxide (CO2) between 32–38 mmHg. To maintain anesthesia, 2–3% sevoflurane kept the bispectral index (BIS) between 40 and 60, and 0.05 mg/kg of the muscle relaxant cisatracurium was added at 40-minute intervals according to the conditions of the operation. No other medication was administered.

Evaluation criteria

The length of hospital stay, operative time (length of time in the operating theater), and intraoperative pain rates were recorded. Adverse reactions within 24 h after surgery, postoperative patient satisfaction rates, and neurological complications were assessed. Visual analog scale (VAS) score and the Oswestry disability index (ODI) were assessed at 3, 6, and 12 months postoperatively.

Statistical analysis

The measurement data are expressed as the mean ± standard deviation. Differences among measurement data were statistically analyzed by Student’s t-test. Enumerated data are expressed as percentages and were compared by the chi-square test. Statistical significance was considered to exist when P<0.05.


There were no significant differences in the baseline values between the two groups. However, the mean operative time in the LA group was lower than in the GA group (50.12±23.65 and 78.64±19.12 min, respectively; P<0.01). Length of hospital stay was shorter in the LA group (3.3±0.47 days) than in the GA group (4.7±0.96 days) (Table 1).

Table 1
Table 1 The baselines and operative data of the two groups
Full table

In the LA group, none of the patients suffered cauda equina nerve or nerve root injury. Half of the patients (50%) feared receiving the surgery with LA, while all patients were willing to undergo the same surgery under GA. In the GA group, one patient suffered nerve root injury intraoperatively. Three months after nutrition and rehabilitation treatment, the patient’s muscle strength had recovered from grade 2 to grade 4. Adverse reactions were experienced by 8% (2/30) of the patients in the LA group and 18% (6/30) of the patients in the GA group (Table 2).

Table 2
Table 2 Comparison of adverse reactions, patient feeling between the local group and the general group
Full table

As shown in Figure 2, the postoperative ODI and VAS scores decreased (P<0.05) from 3 months postoperative to 12 months postoperative. However, there were no significant differences between the two groups at the 3-, 6- and 12-month postoperative follow-up time points (P>0.05).

Figure 2 Comparison of ODI, VAS between the local group and the general group. ODI, Oswestry disability index; VAS, visual analog scale. *, P<0.05.


In recent years, LA has been established as an effective, reliable, and successful alternative to GA for lumbar surgery (14-16). Due to the sensory blockade applied in GA, cauda equina nerve and nerve root injury are difficult to detect. For these reasons, most surgeons, especially those with less experience, prefer LA.

Nevertheless, LA had disadvantages: operative anxiety and anesthesia-induced stress reactions, immune suppression, and inflammatory reactions (17). Wang found that continuous epidural anesthesia had more advantages than LA in improving the immune function of patients undergoing PELD for lumbar intervertebral disc herniation and proposed that painless surgery would reduce the adverse psychological effects, such as postoperative anxiety (18). In this study, 66.66% (20/30) of patients felt pain intraoperatively, and 6 patients (6/30) felt unbearable pain in the LA group. Therefore, the patients in the GA group had better immune suppression and inflammatory reactions than those in the LA group. In modern society, more attention is paid to patients’ intraoperative psychology. Surgical experience (19-21) is becoming increasingly important as good surgical experiences are associated with good postoperative clinical results. In the LA group, 15 patients feared undergoing reoperation, but no patients in the GA group feared undergoing reoperation, which indicates that the patients in the GA group had better surgical experiences.

Compared with the LA group, the GA group had longer operative times and hospital stays. However, the differences between the groups were only half an hour and one day, respectively, and can possibly be attributed to preparation time for GA and recovery time from tracheal intubation. Adverse reactions, VAS scores, ODIs, postoperative patient satisfaction rates, and neurological complications were similar between the two groups. Thus, there were no significant differences between the clinical results of the two groups.

There is a learning curve associated with endoscopic techniques. After at least 72 surgical procedures, 90% of cases have good/excellent results (22). In this study, one patient in the GA group sustained nerve root injury. Electromyography (EMG) could assist skilled surgeons in reducing nerve root injury during lumbar interlaminar endoscopic surgery with GA.

This study had some limitations that need to be addressed. Firstly, only lumbar interlaminar endoscopic surgery was evaluated. Secondly, the study lacks large sample size calculations and long follow-up times. Further research with larger sample sizes and longer follow-up time is required.


GA and LA are both effective for lumbar interlaminar endoscopic surgery. However, GA makes a positive intraoperative surgical experience more likely for the patient.


Funding: This work was supported by Basic Public Welfare Project of Zhejiang Province (No. LGF19H060008) and Wenzhou Bureau of Science and Technology Project (No: 2018Y1551).


Reporting Checklist: The authors have completed the CONSORT reporting checklist. Available at

Data Sharing Statement: Available at

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. This study was approved by The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Research Ethics Committee Meeting (No. LCKY2019-287).

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See:


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Cite this article as: Ye XF, Wang S, Wu AM, Xie LZ, Wang XY, Chen JX, Xu H, Sheng SR. Comparison of the effects of general and local anesthesia in lumbar interlaminar endoscopic surgery. Ann Palliat Med 2020;9(3):1103-1108. doi: 10.21037/apm-20-623