Lupus podocytopathy complicated with multiple organ injuries in a patient with severe lupus

Jianhong Wu, Fanxin Zeng, Xuejun Jiang, Tingting Wang, Chaoqiong Yao


To investigate the clinical manifestations, pathological features, treatment, and prognosis of a special type of podocytopathy in patients with lupus nephritis (LN). The clinical data, including clinical manifestations, pathological features, immunological markers, treatment, and prognosis of one patient with lupus podocytopathy (LP), were retrospectively analyzed. Relevant literature was also reviewed. The patient was clinically diagnosed with a rare type of LP-based on medical history, clinical manifestations, laboratory tests, renal biopsy results, and relevant literature. After treatment with steroids combined immunosuppressive agents, the clinical symptoms were improved, and the nephropathy was completely reversed. The disease condition was stable during follow-up. LP is a specific pathological change in the spectrum of LN, with nephrotic syndrome (NS) as its primary clinical manifestation. Patients may also have severe lupus-associated injuries affecting multiple systems. Immunosuppressive agents combined with steroids can improve clinical symptoms.