Cancer pain management: What should be done to improve effectiveness?
Cite this article as: So WK. Cancer pain management: what should be done to improve effectiveness? Ann Palliat Med 2012;1(1):8-9. DOI: 10.3978/ j.issn.2224-5820.2012.02.01
Editorial

Cancer pain management: What should be done to improve effectiveness?

Winnie K.W. So

The Nethersole School of Nursing, The Chinese University of Hong Kong, Hong Kong SAR, China

Corresponding to:
Winnie K.W. So, PhD. The Nethersole School of Nursing, The Chinese University of Hong Kong, Rm 731, 7/F, Esther Lee Building, New Territories Hong Kong SAR, China.
Tel: (852) 3943 1072; Fax: (852) 2603 5269. Email: winnieso@cuhk.edu.hk.

Ann Palliat Med 2012;1(1):8-9. DOI: 10.3978/j.issn.2224-5820.2012.02.01

In 2008, the International Agency for Research on Cancer (1) estimated that there were more than 12.4 million new cancer cases worldwide, 7.6 million deaths from the disease, and 28 million people with cancer surviving five years after initial diagnosis. Advances in cancer treatment have increased survival rates and prolonged life spans (2), but there is still inevitable damage to healthy cells and tissues due either to the cancer itself or to the therapy applied, and side effects or symptoms therefore occur during or after the treatment. Among the various symptoms experienced by cancer patients, pain is one of the most prevalent (3).

Defined as 'unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage' (4), pain is one of the most distressful symptoms suffered by cancer patients (5,6), and can occur at various times throughout the cancer trajectory. Unrelieved pain greatly affects patients' daily living activities, emotions and quality of life (7,8). A comprehensive pain assessment and the ready availability of effective therapies are essential for relieving cancer pain.

In this issue of The Annals of Palliative Medicine, Situ et al. (9) use another lens to examine present evidence on the assessment and management of cancer pain. Their paper provides an overview of developments in cancer pain classification and assessment, as well as considering the effectiveness of various treatments. While the classification and assessment of pain together form a crucial step in optimal pain management, the findings of this review show a lack of comprehensive validation in existing classifications and assessments. Although various tools have been developed, there is no universal accepted tool for pain assessment in palliative care settings. Another problem identified in the review is the applicability of pain assessment tools to both research and clinical practice. While a comprehensive, multidimensional and systematic pain assessment is essential, it may increase the burden of clinicians and patients and, in turn, decrease compliance and application rates. Developing and validating a standardised cancer pain classification and practical assessment system through international collaboration seems to be the best way forward, and Situ et al.'s review (9) provides important insights into gaps that need to be addressed by future research.

The most widely accepted algorithm for the treatment of cancer pain was developed by the World Health Organisation (WHO) (10). It suggests that patients with pain be started (in the following order) on nonopioids such as paracetamol or a non-steroidal anti-inflammatory drug (NSAID), then a 'mild opioid' such as codeine, and then a 'strong opioid' such as morphine, until the patient's pain is relieved. According to the WHO report, this algorithm is 80-90% effective provided that patients receive the right drug in the right dose at the right time (10).

While opioid-based pharmaceutical therapy is still the main method of cancer pain management, the use of other non-opioid pharmaceutical therapies or non-pharmaceutical methods such as adjuvant therapy has been proven effective (9). Various clinical guidelines also provide for different types of therapy (11,12). However, the Situ et al. (9) paper presents additional evidence concerning alternative treatments commonly used in Chinese culture: acupuncture, massage and Chinese herbal medicine. It is likely that a combination of both Western and Eastern approaches to cancer pain management will prove to be necessary. However, further research is needed to examine the effectiveness of this dual approach.

Pain is a subjective experience which is too complex to deal with through a single algorithm. More international collaboration is needed to develop a universal and practical tool for pain assessment in the palliative care setting, and more research should be conducted to evaluate the effectiveness of a combined Western and Eastern therapy - always bearing in mind, of course, that clinicians must ensure the needs of the individual patient are addressed in any implementation of cancer pain management.


References

  1. World Cancer Report 2008. In: Boyle P, Levin B, editors. International Agency for Research on Cancer 2008. Available online: http://www.iarc. fr/en/publications/pdfs-online/wcr/2008/index.php[LinkOut]
  2. National Cancer Institute. Surveillance epidemiology and end results [Accessed December 31, 2011]. Available online: http://seer.cancer.gov/ faststats/index.php[LinkOut]
  3. Patrick DL, Ferketich SL, Frame PS, et al. National Institutes of Health State-of-the-Science Conference Statement: Symptom management in cancer: pain, depression, and fatigue, July 15-17, 2002. J Natl Cancer Inst Monogr 2004;(32):9-16.[LinkOut]
  4. Bonica JJ. The need of a taxonomy. Pain 1979;6:247-8.[LinkOut]
  5. Molassiotis A, Zheng Y, Denton-Cardew L, et al. Symptoms experienced by cancer patients during the first year from diagnosis: patient and informal caregiver ratings and agreement. Palliat Support Care 2010;8:313-24.[LinkOut]
  6. Spichiger E, Müller-Fröhlich C, Denhaerynck K, et al. Symptom prevalence and changes of symptoms over ten days in hospitalized patients with advanced cancer: a descriptive study. Eur J Oncol Nurs 2011;15:95-102.[LinkOut]
  7. Funk GF, Karnell LH, Christensen AJ. Long-term Health-Related Quality of Life in Survivors of Head and Neck Cancer. Arch Otolaryngol Head Neck Surg 2012. [Epub ahead of print]
  8. So WK, Marsh G, Ling WM, et al. The symptom cluster of fatigue, pain, anxiety, and depression and the effect on the quality of life of women receiving treatment for breast cancer: a multicenter study. Oncol Nurs Forum 2009;36:E205-14.[LinkOut]
  9. Situ D, Wang J, Shao W et al. Assessment and treatment of cancer pain: from Western to Eastern. Ann Palliat Med 2011.
  10. World Health Organization. WHO’s pain ladder. [Accessed 26 January 2012]. Available online: http://www.who.int/cancer/palliative/ painladder/en/[LinkOut]
  11. SIGN Scottish Intercollegiate Guidelines Network. Control of pain in adults with cancer: quick reference guide. Edinburgh: Scottish Intercollegiate Guidelines Network. 2008. Available online: http://www. sign.ac.uk/pdf/qrg106.pdf[LinkOut]
  12. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Adult Cancer Pain Version 2. 2011.

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